I had a patient ask recently about the use of valium suppositories for pelvic pain due to tight muscles. Specifically they were concerned about whether or not the medication would be felt in the rest of the body.
At the moment I didn't have a good answer, but I promised to look into it. Fortunately I found an excellent study that addressed this exact question. I was so interested in the result that I wanted to share with the rest of my patients!
The study is: Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile, and it was published by Larish, Dickson, Kudgus, McGovern, Reid, Hooten, Nicholson, Vaughan, Burnett, Laughlin-Tommaso, Faubion, and Green in the Journal of Sexual Medicine in 2019.
The take-home points are:
Here is the study abstract if you want to check it out yourself-
I hope that this was of interest to you! f you would like to discuss this further, don't hesitate to reach out.